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COSMOSIL CHROMATOGRAPHY COLUMNS

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BuckyPrep Column	BuckyPrep-M Column
5mPBB Column	5PYE Column

5mPBB-R Column NEW!!	5C4-AR-300 Column
5NPE Column	5C4-MS Column
5C8-AR-300 Column	5TMS-MS Column
5Ph-AR-300 Column	5C8-MS Column
5C18-AR Column	5PE-MS Column
5C18-AR-II Column	5CN-MS Column
5C18-MS Column	5NH2-MS Column
5C18-MS-II Column	5GPC-60, 100, 300 Column
5C18-PAQ Column	5DIOL-120, 300 Column
5HIC Column	5SL-II Column (Normal Phase)
5CSP-HPR Column NEW!!	SMILE Capillary Electrophoresis Column
5C18-AR-300 Column	Sugar-D Column NEW!!
5C18-P-MS Column	Cholester Column NEW!!
HILIC Column NEW!!	Cosmogel Protein-R Column

Please contact us to receive a 142 page Cosmosil Catalog
or
Click on this link to download a copy of the complete catalog

COSMOSIL®	Bounded ligand	C(%)	Special features and Applications
Buckyprep	pyrenylpropyl group	17	Economical preparative separation of fullerenes (higher fullerenes, metal containing fullerenes) on an analytical HPLC system.
Buckyprep-M	phenodiazin group	-	Designed to separate metallofullerenes in economical solvent (Toluene).
5PBB	pentabromo benzyl group	8	Designed for the preparative separation of fullerenes using carbon disulphide or toluene as mobile phase.
5PYE	pyrenyl ethyl group	-	Multiple separation modes including hydrophobic interaction, charge transfer and π - π interaction makes this column very unique. Especially useful for structural isomer separation.
5C18-MS-II	octadecyl group	16	Monofunctional silylation on ultra-pure silica gel makes this column suitable for the separation of a wide range of compounds.
5C18-AR-II	octadecyl group	17	Multi-purpose, ultra-pure silica gel based polymeric C18 column with exceptionally strong acid resistance.
5C18-PAQ	octadecyl group	11	Reversed phase HPLC column, compatible with 100 % water based mobile phases!
5C18-P-MS	octadecyl group	9	Generally recommended to improve retention of very polar compounds.
NEW!! Cholester	Cholesteryl group	20	Cholester is the best “Second-choice” column for reversed phase chromatography. The rigid-structure of Choresteryl-group solves your problems.
5NPE	nitrophenyl ethyl group	9	Similar to the PYE column with multiple separation modes. Very useful for separations impossible with standard alkyl chain columns.
C18,C8,C4,Ph AR-300	alkyl or pheny group	-	Wide pore reversed phase column with high acid resistance recommended for the separation of proteins, polypeptides, nucleic acids and other large molecules.
5Diol-120-II 5Diol-300-II	diol group	9	Silica-based gel filtration column for high-speed separation of proteins and enzymes.
5HIC	-	-	Hydrophobic Interaction Chromatography column for protein separation.
5C8-MS	octyl group	10	Shorter retention than C18-MS-II but otherwise provides excellent separation for many compounds
5C4-MS	butyl group	7	Short alkyl chain length suitable for the separation of more hydrophobic compounds.
5TMS-MS	trimethyl group	5	Provides greater retention for aromatic compounds
5PE-MS	phenylethyl group	10	Provides greater retention for aromatic compounds
5CN-MS	cyanopropyl group	7	Alternative to improve peak shape or shorter retention times
5SL-II	-	-	Normal phase chromatography without ionic additives
NEW!! HILIC	Triazole group	-	A new column for hydrophilic interaction chromatography. Retains highly polar compounds that would not be retained in C18 columns.
5GPC	alkyl group	-	Columns for organic GPC of polymers, choice of 60 A, 100 A, 300 A pore sizes.
NEW!! Sugar-D	-	-	We have succeeded in creating a new, powerful HPLC column that has significantly longer active life and excellent retention of saccharides.
5NH2-MS	aminopropyl group	4	Normally used for reversed phase chromatography of various mono-, di- and oligosaccharides but can also be used in normal phase adsorption chromatography with non-polar organic solvents.
5CSP-HPR	-	-	Ligand exchange type chiral column for oxy-acid amino acid separation.
C18-OPN	octadecyl group	-	For open column reversed phase chromatography
C18-PREP	octadecyl group	-	For medium pressure or open column reversed phase chromatography
SL-II-PREP	-	-	For medium pressure or open column normal phase chromatography
Silica Gel 60-N	-	-	Neutral pH for the medium pressure chromatography separation of delicate molecules

To learn more about COSMOSIL
please see our Presentation

The Structure of the Columns
Ferrule Type
	1.tube 2.end-fitting 3.nut 4.ferrule 5.plug 6.filter

Screw-in Type
	1.tube 2.end-fitting 3.filter 4.plug

Please contact us to receive a 142 page Cosmosil Catalog

Chromatography Columns

The reversed phase HPLC column is most commonly used column due to the high theoretical plate numbers, excellent separation characteristics, reproducibility, cost performance and ease of use. Columns packed with the octadecyl group bounded type silica gel (C₁₈, ODS) are the most widely used today. While C18 columns are most widely used in reversed phase chromatography, it is important to distinguish between two very different types of bounded C₁₈ phase formats.

A monomeric type C₁₈ format incorporates the bonding of the C₁₈ alkyl chain to a single silica atom on the silica gel backbone. Monomeric type columns such as the COSMOSIL MS series have excellent synthesis reproducibility, very good lot-to-lot reproducibility and short mobile phase equilibration times. On the other hand, the polymeric C₁₈ format incorporates a tri-functional silylation procedure whereby the octadecyl group is bonded to 2 or 3 silica atoms on the silica gel backbone. This increased silylation results in far greater column stability particularly in acidic mobile phase conditions. Stereo recognition capability is also greater than that of the monofunctional silylation type C₁₈column. The polymeric format is offered in the COSMOSIL AR series columns. Also along with the C18 columns there are three other special designed reversed columns: BuckyPrep, PBB and PYE columns.

Structure of various stationary phase

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Tel. (713) 686-9662 Fax. (713) 686-9635 1-800-275-0082

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COSMOSIL CHROMATOGRAPHY COLUMNS

C18-OPN

C18-PREP

Silica Gel 60-N