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This column is based on an ultra-pure silica gel (more than 99.99%) with carbon content of only 8.5%. Therefore the retention of polar compounds is relatively longer than that on the C18-MS-II or C18-AR-II. This column is also suitable for the analysis of a wide range of chemical compounds including polypeptides.
high purity porous spherical silica
Average particle size
Average pore size
Specific surface area
monomeric type octadecyl group
End capping treatment
Comparison data using different COSMOSIL ® C 18 columns
The COSMOSIL ® 5C 18 -P-MS gives quicker separation of most samples compared with other COSMOSIL ® 5C 18 type columns. However, there is a characteristic by which the polar compounds are retained relatively longer on the COSMOSIL ® 5C 18 -P-MS.
Separation of di-substituted benzene isomers
Because their characteristics (eg. polarity) and structure is very similar, isomers of di-substituted benzene are one of the most difficult samples to separate. It is possible to separate them at a high probability by using either any or a combination of three types of COSMOSIL ® C 18 (MS-II, AR-II, P-MS).