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This column is based on an ultra-pure silica gel (more than 99.99%) with carbon content of only 8.5%. Therefore the retention of polar compounds is relatively longer than that on the C18-MS-II or C18-AR-II. This column is also suitable for the analysis of a wide range of chemical compounds including polypeptides.
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MATERIAL CHARACTERISTICS
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COSMOSIL 5C18-P-MS
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Silica gel
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high purity porous spherical silica
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Average particle size
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5µm
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Average pore size
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approx. 120Å
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Specific surface area
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approx. 300m²/g
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Stationary phase
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monomeric type octadecyl group
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End capping treatment
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near-perfect treatment
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Carbon content
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approx. 8.5%
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Comparison data using different COSMOSIL ® C 18 columns
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The COSMOSIL ® 5C 18 -P-MS gives quicker separation of most samples compared with other COSMOSIL ® 5C 18 type columns. However, there is a characteristic by which the polar compounds are retained relatively longer on the COSMOSIL ® 5C 18 -P-MS.
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Separation of di-substituted benzene isomers
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| Because their characteristics (eg. polarity) and structure is very similar, isomers of di-substituted benzene are one of the most difficult samples to separate. It is possible to separate them at a high probability by using either any or a combination of three types of COSMOSIL ® C 18 (MS-II, AR-II, P-MS). |
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