This column is based on an ultra-pure silica gel (more than 99.99%) with carbon content of only 8.5%. Therefore the retention of polar compounds is relatively longer than that on the C18-MS-II or C18-AR-II. This column is also suitable for the analysis of a wide range of chemical compounds including polypeptides. MATERIAL CHARACTERISTICS | | | COSMOSIL 5C18-P-MS | Silica gel | high purity porous spherical silica | Average particle size | 5µm | Average pore size | approx. 120Å | Specific surface area | approx. 300m²/g | Stationary phase | monomeric type octadecyl group | End capping treatment | near-perfect treatment | Carbon content | approx. 8.5% |
Comparison data using different COSMOSIL ® C 18 columns | The COSMOSIL ® 5C 18 -P-MS gives quicker separation of most samples compared with other COSMOSIL ® 5C 18 type columns. However, there is a characteristic by which the polar compounds are retained relatively longer on the COSMOSIL ® 5C 18 -P-MS.
| Separation of di-substituted benzene isomers | | Because their characteristics (eg. polarity) and structure is very similar, isomers of di-substituted benzene are one of the most difficult samples to separate. It is possible to separate them at a high probability by using either any or a combination of three types of COSMOSIL ® C 18 (MS-II, AR-II, P-MS). |
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