COLUMNS



 

Fullerenes Relates Columns

HPLC Accessories COSMO Capillary
5C4-AR-300 Column
5NPE Column 5C4-MS Column
5C8-AR-300 Column 5TMS-MS Column
5Ph-AR-300 Column 5C8-MS Column
 5C18-AR-II Column 5PE-MS Column
5C18-MS-II Column 5CN-MS Column
 5C18-PAQ Column 5NH2-MS Column
5C18-AR-300 Column  5DIOL-120, 300 Column
5C18-PAQ Column Cosmogel Protein-R Column
5HIC Column 5SL-II Column (Normal Phase)
 HILIC Colum  Cholester Column

 

COSMOSIL®
Bounded ligand
C(%)
Special features and Applications

Buckyprep

pyrenylpropyl group
17
Economical preparative separation of fullerenes (higher fullerenes, metal containing fullerenes) on an analytical HPLC system.

Buckyprep-D

Nitro-carbazoyl group
For separation of fullerene derivatives

Buckyprep-M

phenodiazin group
Designed to separate metallofullerenes in economical solvent (Toluene).

CNT

Hydrophilic group
Size-based separation of soluble carbon nanotubes, High durability.

5PBB

pentabromo benzyl group
8
Designed for the preparative separation of fullerenes using carbon disulphide or toluene as mobile phase.

5PYE

pyrenyl ethyl group
Multiple separation modes including hydrophobic interaction, charge transfer and π – π interaction makes this column very unique. Especially useful for structural isomer separation.

5C18-MS-II

octadecyl group
16
Monofunctional silylation on ultra-pure silica gel makes this column suitable for the separation of a wide range of compounds.

5C18-AR-II

octadecyl group
17
Multi-purpose, ultra-pure silica gel based polymeric C18 column with exceptionally strong acid resistance.

5C18-PAQ

octadecyl group
11
Reversed phase HPLC column, compatible with 100 % water based mobile phases!

5C18-P-MS

octadecyl group
9
Generally recommended to improve retention of very polar compounds.

Cholester

Cholesteryl group
20
Cholester is the best “Second-choice” column for reversed phase chromatography. The rigid-structure of Choresteryl-group solves your problems.

5NPE

nitrophenyl ethyl group
9
Similar to the PYE column with multiple separation modes. Very useful for separations impossible with standard alkyl chain columns.

C18,C8,C4,Ph
AR-300

alkyl or pheny group
Wide pore reversed phase column with high acid resistance recommended for the separation of proteins, polypeptides, nucleic acids and other large molecules.

5Diol-120-II
5Diol-300-II

diol group
9
Silica-based gel filtration column for high-speed separation of proteins and enzymes.

5HIC

Hydrophobic Interaction Chromatography column for protein separation.

5C8-MS

octyl group
10
Shorter retention than C18-MS-II but otherwise provides excellent separation for many compounds

5C4-MS

butyl group
7
Short alkyl chain length suitable for the separation of more hydrophobic compounds.

5TMS-MS

trimethyl group
5
Provides greater retention for aromatic compounds

5PE-MS

phenylethyl group
10
Provides greater retention for aromatic compounds

5CN-MS

cyanopropyl group
7
Alternative to improve peak shape or shorter retention times

5SL-II

Normal phase chromatography without ionic additives
Triazole group
A new column for hydrophilic interaction chromatography. Retains highly polar compounds that would not be retained in C18 columns.

5GPC

alkyl group
Columns for organic GPC of polymers, choice of 60 A, 100 A, 300 A pore sizes.
We have succeeded in creating a new, powerful HPLC column that has significantly longer active life and excellent retention of saccharides.

5NH2-MS

aminopropyl group
4
Normally used for reversed phase chromatography of various mono-, di- and oligosaccharides but can also be used in normal phase adsorption chromatography with non-polar organic solvents.

5CSP-HPR

Ligand exchange type chiral column for oxy-acid amino acid separation.

C18-OPN

octadecyl group
For open column reversed phase chromatography

C18-PREP

octadecyl group
For medium pressure or open column reversed phase chromatography

SL-II-PREP

For medium pressure or open column normal phase chromatography

Silica Gel 60-N

Neutral pH for the medium pressure chromatography separation of delicate molecules

To learn more about COSMOSIL
please see our Presentation

The Structure of the Columns
Ferrule Type
Cosmosil Column SES
1.tube
2.end-fitting
3.nut
4.ferrule
5.plug
6.filter
Screw-in Type
Cosmosil Column SES
1.tube
2.end-fitting
3.filter
4.plug

Please contact us to receive a 142 page Cosmosil Catalog

Chromatography Columns

The reversed phase HPLC column is most commonly used column due to the high theoretical plate numbers, excellent separation characteristics, reproducibility, cost performance and ease of use. Columns packed with the octadecyl group bounded type silica gel (C18, ODS) are the most widely used today. While C18 columns are most widely used in reversed phase chromatography, it is important to distinguish between two very different types of bounded C18 phase formats.

A monomeric type C18 format incorporates the bonding of the C18 alkyl chain to a single silica atom on the silica gel backbone. Monomeric type columns such as the COSMOSIL MS series have excellent synthesis reproducibility, very good lot-to-lot reproducibility and short mobile phase equilibration times. On the other hand, the polymeric C18 format incorporates a tri-functional silylation procedure whereby the octadecyl group is bonded to 2 or 3 silica atoms on the silica gel backbone. This increased silylation results in far greater column stability particularly in acidic mobile phase conditions. Stereo recognition capability is also greater than that of the monofunctional silylation type C18 column. The polymeric format is offered in the COSMOSIL AR series columns. Also along with the C18 columns there are three other special designed reversed columns: BuckyPrep, PBB and PYE columns.

Structure of various stationary phase

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