COSMOSIL®Bounded ligandC(%)Special features and Applications
Buckypreppyrenylpropyl group17Economical preparative separation of fullerenes (higher fullerenes, metal containing fullerenes) on an analytical HPLC system.
Buckyprep-DNitro-carbazoyl groupFor separation of fullerene derivatives
Buckyprep-Mphenodiazin groupDesigned to separate metallofullerenes in economical solvent (Toluene).
CNTHydrophilic groupSize-based separation of soluble carbon nanotubes, High durability.
5PBBpentabromo benzyl group8Designed for the preparative separation of fullerenes using carbon disulphide or toluene as mobile phase.
5PYEpyrenyl ethyl groupMultiple separation modes including hydrophobic interaction, charge transfer and π – π interaction makes this column very unique. Especially useful for structural isomer separation.
5C18-MS-IIoctadecyl group16Monofunctional silylation on ultra-pure silica gel makes this column suitable for the separation of a wide range of compounds.
5C18-AR-IIoctadecyl group17Multi-purpose, ultra-pure silica gel based polymeric C18 column with exceptionally strong acid resistance.
5C18-PAQoctadecyl group11Reversed phase HPLC column, compatible with 100 % water based mobile phases!
5C18-P-MSoctadecyl group9Generally recommended to improve retention of very polar compounds.
CholesterCholesteryl group20Cholester is the best “Second-choice” column for reversed phase chromatography. The rigid-structure of Choresteryl-group solves your problems.
5NPEnitrophenyl ethyl group9Similar to the PYE column with multiple separation modes. Very useful for separations impossible with standard alkyl chain columns.
alkyl or pheny groupWide pore reversed phase column with high acid resistance recommended for the separation of proteins, polypeptides, nucleic acids and other large molecules.
diol group9Silica-based gel filtration column for high-speed separation of proteins and enzymes.
5HICHydrophobic Interaction Chromatography column for protein separation.
5C8-MSoctyl group10Shorter retention than C18-MS-II but otherwise provides excellent separation for many compounds
5C4-MSbutyl group7Short alkyl chain length suitable for the separation of more hydrophobic compounds.
5TMS-MStrimethyl group5Provides greater retention for aromatic compounds
5PE-MSphenylethyl group10Provides greater retention for aromatic compounds
5CN-MScyanopropyl group7Alternative to improve peak shape or shorter retention times
5SL-IINormal phase chromatography without ionic additives
HILICTriazole groupA new column for hydrophilic interaction chromatography. Retains highly polar compounds that would not be retained in C18 columns.
Sugar-DWe have succeeded in creating a new, powerful HPLC column that has significantly longer active life and excellent retention of saccharides.
5NH2-MSaminopropyl group4Ligand exchange type chiral column for oxy-acid amino acid separation.
5CSP-HPRFor open column reversed phase chromatography
C18-OPNoctadecyl groupFor medium pressure or open column reversed phase chromatography
C18-PREPoctadecyl groupFor medium pressure or open column normal phase chromatography
SL-II-PREPFor medium pressure or open column normal phase chromatography
Silica Gel 60-NNeutral pH for the medium pressure chromatography separation of delicate molecules


To learn more about COSMOSIL please see our Presentation

The Structure of the Columns
Ferrule Type
Cosmosil Column SES
Screw-in Type
Cosmosil Column SES

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Chromatography Columns

The reversed phase HPLC column is most commonly used column due to the high theoretical plate numbers, excellent separation characteristics, reproducibility, cost performance and ease of use. Columns packed with the octadecyl group bounded type silica gel (C18, ODS) are the most widely used today. While C18 columns are most widely used in reversed phase chromatography, it is important to distinguish between two very different types of bounded C18 phase formats.

A monomeric type C18 format incorporates the bonding of the C18 alkyl chain to a single silica atom on the silica gel backbone. Monomeric type columns such as the COSMOSIL MS series have excellent synthesis reproducibility, very good lot-to-lot reproducibility and short mobile phase equilibration times. On the other hand, the polymeric C18 format incorporates a tri-functional silylation procedure whereby the octadecyl group is bonded to 2 or 3 silica atoms on the silica gel backbone. This increased silylation results in far greater column stability particularly in acidic mobile phase conditions. Stereo recognition capability is also greater than that of the monofunctional silylation type C18 column. The polymeric format is offered in the COSMOSIL AR series columns. Also along with the C18 columns there are three other special designed reversed columns: BuckyPrep, PBB and PYE columns.

Structure of various stationary phase

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