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Saccharides cannot be separated using standard HPLC columns, because these compounds possess low hydrophobicity and are not retained. It is also difficult to obtain good separation even if the compounds are retained, because the composition and structure of these molecules are very similar. The COSMOSIL 5NH2-MS aminopropyl column is highly recommended for the effective separation of monosaccharides and oligosaccharides. These columns are also recommended for adsorption chromatography.